Effectiveness of intra-articular hyaluronic acid compared with oral glucosamine for clinical improvement in patients with knee osteoarthritis in Trujillo-Peru

Abstract

Objectives: To determine the effectiveness for clinical impro­vement of treatment with intra-articular hyaluronic acid (IAHA) compared to treatment with oral glucosamine (OGV) among people with knee osteoarthritis. Material and Methods: An observational, prospective cohort-type study was carried out, consisting of 54 pa­tients. After applying the selection criteria by means of convenience sampling, the group of patients treated with intra-articular hyalu­ronic acid and patients treated with oral glucosamine was chosen. Clinical improvement was assessed by means of the visual analog pain scale and knee angle measurement obtained from the patient’s medical history. Results: The crude regression model showed that those patients who received intra-articular hyaluronic acid had a significantly greater clinical improvement with respect to those who received oral glucosamine both at the first month (RR: 3.00; 95% CI: 1.64-5.48; p < 0.001) and adjusted (RR: 2.97; 95% CI: 1.67; 95% CI: 1.67; p < 0.001). 97; 95% CI:1.67-5.28; p < 0.001); and at the third month (RR: 3.85; 95% CI: 2.03-7.34; p < 0.001) and (RR: 3.85; 95% CI: 2.04-7.25; p < 0.001). Conclusions: Intra-articular hyaluronic acid is more effective for clinical improvement than oral glucosamine in patients with knee osteoarthritis.